Gastroesophageal reflux disease the causes of refractory gerd can be classified as reflux related and nonreflux related (table 1) in the majority of the cases, refractoriness to ppi can be attributed to residual acid reflux, nonacidic or weakly acidic reflux, acid pocket, oesophageal hypersensitivity, and functional heartburn. Ppi-refractory gastroesophageal reflux disease (gerd). Gastroesophageal reflux disease (gerd) is a chronic condition in which patients suffer troublesome symptoms and/or complications as the reflux of stomach contents occurs gerd is a common disease worldwide with the range of estimated prevalence 181–278% in north america, 88–259% in europe, 25–78% in east asia, 87–331% in the middle east, 116% in australia and 230% in south.
ppi-refractory gastroesophageal reflux disease (gerd)
Refractory gastrooesophageal reflux disease eur j gastroenterol hepatol 2008;20:217-223 fass r, sifrim d management of heartburn not responding to proton pump inhibitors gut 2009;58:295-309 dellon es, shaheen nj persistent reflux symptoms in the proton pump inhibitor era: the changing face of gastroesophageal reflux disease. Gastroesophageal reflux disease (gerd) is defined as a condition that develops when the reflux of stomach contents into the esophagus causes troublesome symptoms, esophageal injury, and/or complications. gerd is estimated to affect 10-20% of adults in western countries, on a daily or weekly basis . gerd results from disruption of the anti. Prevalence of gastroesophageal reflux disease and proton pump inhibitor-refractory symptoms. delshad sd(1), almario cv(2), chey wd(3), spiegel bmr(4). author information: (1)cedars-sinai center for outcomes research and education (cs-core), los angeles, california; department of medicine, david geffen school of medicine at ucla, los angeles.
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